Methyl iodide → HCID 20232030, compound

HRID 2290365Notes

Reaction equation

HRID 2290365 reaction equation
[K].[CH3:2][C:3]1[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:7][NH:6][C:5](=[O:15])[N:4]=1.[CH3:16]I>CO>[CH3:16][N:6]1[C:5](=[O:15])[N:4]=[C:3]([CH3:2])[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:7]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 5462222PotassiumHCID 20232012HCID 20232012, compound

Product 1

HCID 20232030HCID 20232030, compoundYield 56.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Potassium salt of 5-methyl-6-phenyl1,2,4-triazin-3(2H)-one (20 g) was dissolved in methanol (200 ml). Methyl iodide (37.8 g) was added thereto, and the solution was refluxed for 2.5 hours, and evaporated under reduced pressure. The resultant residue was washed with water and dissolved in chloroform. The solution was washed with water, dried over magnesium sulfate and concentrated to dryness. The residue was washed with ethyl acetate and dried to give 2,5-dimethyl-6-phenyl-1,2,4-triazin-3(2H)-one (12.11 g).

Workup

  1. temperaturethe solution was refluxed for 2.5 hours
  2. customevaporated under reduced pressure
  3. washThe resultant residue was washed with water
  4. dissolutiondissolved in chloroform
  5. washThe solution was washed with water
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated to dryness
  8. washThe residue was washed with ethyl acetate
  9. customdried

Sources & evidence

ORD record
ord-98ce393de01e4d829f2669d9833f0467
Source dataset
uspto-grants-1986_10
Patent number
US04616014

Reaction notes

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