Methyl iodide → HCID 20232030, compound

Participants

Reaction Steps

Potassium salt of 5-methyl-6-phenyl1,2,4-triazin-3(2H)-one (20 g) was dissolved in methanol (200 ml). Methyl iodide (37.8 g) was added thereto, and the solution was refluxed for 2.5 hours, and evaporated under reduced pressure. The resultant residue was washed with water and dissolved in chloroform. The solution was washed with water, dried over magnesium sulfate and concentrated to dryness. The residue was washed with ethyl acetate and dried to give 2,5-dimethyl-6-phenyl-1,2,4-triazin-3(2H)-one (12.11 g).

Provenance & Evidence