Benzyl Chloride → HCID 15586383, compound

HRID 2290367Notes

Reaction equation

HRID 2290367 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[N:6]=[C:5]([CH3:9])[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:3]1.[CH2:16]([Mg]Cl)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(Cl)C1C=CC=CC=1.[Mg]>C(OCC)C>[CH2:16]([C:5]1([CH3:9])[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:3][N:2]([CH3:1])[C:7](=[O:8])[NH:6]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 7503Benzyl ChlorideHCID 5462224MagnesiumHCID 20232030HCID 20232030, compoundHCID 178418336HCID 178418336, compound

Product 1

HCID 15586383HCID 15586383, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2,5-Dimethyl-6-phenyl-1,2,4-triazin-3(2H)-one (3.2 g) was added to a stirred solution of benzylmagnesium chloride prepared from benzyl chloride (9.99 g) and magnesium turnings (1.92 g) in diethyl ether (48 ml) at room temperature. The reaction mixture was treated in a similar manner to that of Example 30 to give 5-benzyl-2,5-dimethyl-6-phenyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2.6 g), m.p. 174.2°~175.3° C. recrystallized from a mixture of chloroform and diisopropyl ether).

Workup

  1. additionThe reaction mixture was treated in a similar manner to that of Example 30

Sources & evidence

ORD record
ord-2eebf2de268e4d0dbf4a5a761279d80c
Source dataset
uspto-grants-1986_10
Patent number
US04616014

Reaction notes

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