Water → HCID 135544474, compound

HRID 2290369Notes

Reaction equation

HRID 2290369 reaction equation
[OH:1][N:2]=[C:3]([CH3:12])[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[C:13]([NH:16][NH2:17])([NH2:15])=[S:14].O>C(O)(=O)C>[OH:1][N:2]=[C:3]([CH3:12])[C:4](=[N:17][NH:16][C:13]([NH2:15])=[S:14])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 2723789ThiosemicarbazideHCID 63990241,2-Propanedione, 1-phenyl-, 2-oxime

Product 1

HCID 135544474HCID 135544474, compoundYield 86.6%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 2-hydroxyiminopropiophenone (150 g) and thiosemicarbazine (90 g) in acetic acid (500 ml) was heated at 60° C. for 60 hours with stirring. After cooling, water was added to the reaction mixture. The resultant precipitates were collected by filtration, washed successively with water, methanol and diisopropyl ether, and dried to give 2-hydroxyiminopropiophenone thiosemicarbazone (188.2 g).

Workup

  1. temperatureAfter cooling
  2. customThe resultant precipitates
  3. filtrationwere collected by filtration
  4. washwashed successively with water, methanol and diisopropyl ether
  5. customdried

Sources & evidence

ORD record
ord-562e054d1962401c9387696941169c96
Source dataset
uspto-grants-1986_10
Patent number
US04616014

Reaction notes

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