Propylene Oxide → HCID 13135958, compound

HRID 2290448Notes

Reaction equation

HRID 2290448 reaction equation
[N:1]1([C:7]2[CH:19]=[CH:18][C:10]([C:11]([O:13][CH2:14][CH2:15][CH2:16][CH3:17])=[O:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:20]1[O:23][CH:21]1[CH3:22]>CO>[OH:23][CH:21]([CH3:22])[CH2:20][C:7]1[CH:19]=[CH:18][C:10]([N:4]2[CH2:3][CH2:2][N:1]([C:7]3[CH:8]=[CH:9][C:10]([C:11]([O:13][CH2:14][CH2:15][CH2:16][CH3:17])=[O:12])=[CH:18][CH:19]=3)[CH2:6][CH2:5]2)=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 6378Propylene OxideHCID 1580057Butyl 4-piperazin-1-ylbenzoate

Product 1

HCID 13135958HCID 13135958, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 13.1 g. (50 mmole) n-butyl 4-(piperazin-1-yl)-benzoate, 2.9 g. (50 mmole) propylene oxide and 6 ml. methanol is stirred for 24 hours at 20° C. The solvent is then evaporated off and the residue is triturated with ligroin to give a yield of 78% of theory of the desired product; m.p. 85°-86° C.

Workup

  1. additionA mixture of 13.1 g
  2. customThe solvent is then evaporated off
  3. customthe residue is triturated with ligroin

Sources & evidence

ORD record
ord-be3ec272440148379da5acc7192814ab
Source dataset
uspto-grants-1986_10
Patent number
US04616086

Reaction notes

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