HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 53766112 | HCID 53766112 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 54548307 | HCID 54548307 | — |
Reaction Steps
A mixture of 40 mmole methyl 4-[1-(n-hexadecyl)-piperazin-4-ylmethyl]-benzoate, 100 ml. 6N hydrochloric acid and 20 ml. dioxan is maintained at reflux temperature for 16 hours, then concentrated, cooled and suction filtered. After recrystallisation from a DMF-water mixture, there is obtained a yield of 62% of theory of the desired product as a hydrochloride; m.p. 245° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04616086 |
| Source dataset | uspto-grants-1986_10 |
| ORD ID | ord-fba9edfcb32345a1a23523ffaceaa0b6 |
| Source note | uspto-grants-1986_10 |