Hydrochloric Acid → Hydrochloric Acid

HRID 2290454Notes

Reaction equation

HRID 2290454 reaction equation
[CH2:1]([N:17]1[CH2:22][CH2:21][N:20]([CH2:23][C:24]2[CH:33]=[CH:32][C:27]([C:28]([O:30]C)=[O:29])=[CH:26][CH:25]=2)[CH2:19][CH2:18]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[ClH:34]>O1CCOCC1>[CH2:1]([N:17]1[CH2:18][CH2:19][N:20]([CH2:23][C:24]2[CH:25]=[CH:26][C:27]([C:28]([OH:30])=[O:29])=[CH:32][CH:33]=2)[CH2:21][CH2:22]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[ClH:34]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53766112HCID 53766112, compound

Product 2

HCID 313Hydrochloric AcidHCID 54548307HCID 54548307, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 40 mmole methyl 4-[1-(n-hexadecyl)-piperazin-4-ylmethyl]-benzoate, 100 ml. 6N hydrochloric acid and 20 ml. dioxan is maintained at reflux temperature for 16 hours, then concentrated, cooled and suction filtered. After recrystallisation from a DMF-water mixture, there is obtained a yield of 62% of theory of the desired product as a hydrochloride; m.p. 245° C.

Workup

  1. temperatureat reflux temperature for 16 hours
  2. concentrationconcentrated
  3. temperaturecooled
  4. filtrationsuction filtered
  5. customAfter recrystallisation from a DMF-water mixture

Sources & evidence

ORD record
ord-fba9edfcb32345a1a23523ffaceaa0b6
Source dataset
uspto-grants-1986_10
Patent number
US04616086

Reaction notes

Loading…