Acetic Anhydride → HCID 70468775, compound

HRID 2290477Notes

Reaction equation

HRID 2290477 reaction equation
Cl.Cl.Cl.[C:4]([C:7]1[CH:31]=[CH:30][C:10]([CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH:20]([O:22][C:23]3[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=3)[CH3:21])[CH2:15][CH2:14]2)=[CH:9][CH:8]=1)([OH:6])=[O:5].[C:32](OC(=O)C)(=[O:34])[CH3:33]>>[C:4]([C:7]1[CH:8]=[CH:9][C:10]([CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][N:16]([CH2:19][CH:20]([O:22][C:23]3[CH:24]=[CH:25][C:26]([NH:29][C:32]([CH3:33])=[O:34])=[CH:27][CH:28]=3)[CH3:21])[CH2:17][CH2:18]2)=[CH:30][CH:31]=1)([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 20232690HCID 20232690, compound

Product 1

HCID 70468775HCID 70468775, compound

Procedure

A mixture of 9.3 g. (18.9 mmole) 1-(4-carboxyphenethyl)-4-[2-(4-aminophenoxy)-propyl]-piperazine trihydrochloride and 50 ml. acetic anhydride is kept for 2 hours at 100° C. and then cooled. The precipitate obtained is filtered off with suction and recrystallised from acetic acid. There are obtained 8.2 g. (87% of theory) of the desired compound in the form of a dihydrochloride; m.p. 234°-235° C.

Workup

  1. additionA mixture of 9.3 g
  2. temperaturecooled
  3. customThe precipitate obtained
  4. filtrationis filtered off with suction
  5. customrecrystallised from acetic acid
  6. customThere are obtained 8.2 g

Sources & evidence

ORD record
ord-49db301bacf446c6b8bceb60030e80a6
Source dataset
uspto-grants-1986_10
Patent number
US04616086

Reaction notes

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