Acetic Anhydride → HCID 70468775, compound

Participants

Reaction Steps

A mixture of 9.3 g. (18.9 mmole) 1-(4-carboxyphenethyl)-4-[2-(4-aminophenoxy)-propyl]-piperazine trihydrochloride and 50 ml. acetic anhydride is kept for 2 hours at 100° C. and then cooled. The precipitate obtained is filtered off with suction and recrystallised from acetic acid. There are obtained 8.2 g. (87% of theory) of the desired compound in the form of a dihydrochloride; m.p. 234°-235° C.

Provenance & Evidence