HRID2290481

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID149026

Tetrafluoro-m-phenylenediamine dihydrochloride

C6H6Cl2F4N2

HCID20232701

未命名化合物

HCID53728250

未命名化合物

PRODUCTS

生成物

HCID149026

Tetrafluoro-m-phenylenediamine dihydrochloride

C6H6Cl2F4N2

结构：CCOC(=O)c1ccc(C(C)CN2CCN(CC=Cc3ccc(Cl)cc3)CC2)cc1

HCID53673856

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

By the reaction of 4-chlorocinnamyl chloride with the dihydrochloride of 4-[1-(piperazin-1-yl)-prop-2-yl]-benzoate in methylene chloride in the presence of triethylamine (analogously to Example 25), there is obtained a yield of 81% of theory of the dihydrochloride of ethyl 4-{1-[1-(4-chlorocinnamyl)-piperazin-4-yl]-prop-2-yl}-benzoate; m.p. 249°-250° C. (recrystallised from ethanol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3498e60470764de69c91d8d677669b74
来源数据集: uspto-grants-1986_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04616086
来源说明: uspto-grants-1986_10

反应 SMILES

[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([CH:6]=[CH:7][CH2:8]Cl)=[CH:4][CH:3]=1.[C:12]1([NH2:23])[C:17]([F:18])=[C:16]([F:19])[C:15]([F:20])=[C:14]([NH2:21])[C:13]=1[F:22].[ClH:24].Cl.[N:26]1([CH2:32][CH:33]([C:35]2[CH:43]=[CH:42][C:38]([C:39]([O-:41])=[O:40])=[CH:37][CH:36]=2)[CH3:34])[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1.[CH2:44](N(CC)CC)[CH3:45]>C(Cl)Cl>[C:12]1([NH2:23])[C:17]([F:18])=[C:16]([F:19])[C:15]([F:20])=[C:14]([NH2:21])[C:13]=1[F:22].[ClH:1].[ClH:24].[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([CH:6]=[CH:7][CH2:8][N:29]2[CH2:30][CH2:31][N:26]([CH2:32][CH:33]([C:35]3[CH:43]=[CH:42][C:38]([C:39]([O:41][CH2:44][CH3:45])=[O:40])=[CH:37][CH:36]=3)[CH3:34])[CH2:27][CH2:28]2)=[CH:4][CH:3]=1