Trifluoroacetic acid → HCID 13733215, compound

HRID 2290525Notes

Reaction equation

HRID 2290525 reaction equation
C(OC([NH:8][CH:9]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]([F:24])=[C:22]3[C:17]([C:18](=[O:35])[C:19]([C:32]([OH:34])=[O:33])=[CH:20][N:21]3[C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)=[CH:16][C:15]=2[F:36])[CH2:10]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[NH2:8][CH:9]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]([F:24])=[C:22]3[C:17]([C:18](=[O:35])[C:19]([C:32]([OH:34])=[O:33])=[CH:20][N:21]3[C:25]3[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=3)=[CH:16][C:15]=2[F:36])[CH2:10]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 20231144HCID 20231144, compound

Product 1

HCID 13733215HCID 13733215, compound

Procedure

A solution of 1.02 g (2 mmol) of 7-[3-t-butoxycarbonylamino-1-pyrrolidinyl]-6,8-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 25 ml of trifluoroacetic acid is stirred at room temperature until gas evolution ceases. The solvent is evaporated and the residue treated with 1N sodium hydroxide and diluted with water. The pH is adjusted to 5.5 with 6N hydrochloric acid. The precipitate is filtered washed with water and ether to give the title compound.

Workup

  1. customThe solvent is evaporated
  2. additionthe residue treated with 1N sodium hydroxide
  3. additiondiluted with water
  4. filtrationThe precipitate is filtered
  5. washwashed with water and ether

Sources & evidence

ORD record
ord-df53d8a043244a3191faa76cf2adbf48
Source dataset
uspto-grants-1986_10
Patent number
US04617308

Reaction notes

Loading…