反应详情

The procedure described in Example 1 was followed, except that 130 g/hour of 2-chloroaniline and 84 g/hour of crotonaldehyde were employed. Distillation from the oil bed under 5 mbar until the bottom temperature reached 250° C., and crystallization of the distillate with xylene, gave 101 g (57% of theory) of 8-chloro-2-methylquinoline of melting point 64° C.

1. distillationDistillation from the oil bed under 5 mbar until the bottom temperature
2. customreached 250° C.
3. customcrystallization of the distillate with xylene