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2-Chloroaniline → 8-Chloro-2-methylquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloroaniline | HCID 7240 | — |
| 反応物 | Crotonaldehyde | HCID 447466 | — |
| 生成物 | 8-Chloro-2-methylquinoline | HCID 221113 | 57% |
反応手順
The procedure described in Example 1 was followed, except that 130 g/hour of 2-chloroaniline and 84 g/hour of crotonaldehyde were employed. Distillation from the oil bed under 5 mbar until the bottom temperature reached 250° C., and crystallization of the distillate with xylene, gave 101 g (57% of theory) of 8-chloro-2-methylquinoline of melting point 64° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04617395 |
| 出典データセット | uspto-grants-1986_10 |
| ORD ID | ord-da50df8f3f3f4fb78c0fb85de7b18430 |
| 出典メモ | uspto-grants-1986_10 |