Methanol → 6-Methoxy-N-(propan-2-yl)pyridin-2-amine

HRID 2290606Notes

Reaction equation

HRID 2290606 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][CH:9]([CH3:11])[CH3:10])[N:3]=1.[OH-:12].[K+].[CH3:14]O>>[CH3:14][O:12][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:8][CH:9]([CH3:11])[CH3:10])[N:3]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 202315866-Bromo-N-(propan-2-yl)pyridin-2-amine

Product 1

HCID 155933506-Methoxy-N-(propan-2-yl)pyridin-2-amine

Procedure

In the same reacting apparatus as in Example 1, 20 g of 2-bromo-6-isopropylaminopyridine, 70 ml of methanol and 14 g of potassium hydroxide were charged and they were subjected to reacting each other at 160° C. for 4 hours. After completion of the reaction, the similar experimental procedure as in Example 3 was carried out to give 7.3 g of 2-methoxy-6-isopropylaminopyridine of b.p. 127°-128° C./20 mmHg.

Workup

  1. additionwere charged
  2. customother at 160° C.
  3. customfor 4 hours
  4. customAfter completion of the reaction

Sources & evidence

ORD record
ord-a5145b4f96e3456982e6bf21b3c7f7a1
Source dataset
uspto-grants-1986_10
Patent number
US04617397

Reaction notes

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