Water → HCID 178433455, compound

HRID 2290612Notes

Reaction equation

HRID 2290612 reaction equation
[OH2:1].[CH3:2][C:3]1[N:8]=[C:7](Cl)[CH:6]=[C:5]([Cl:10])[N:4]=1.[OH-].[Na+].[Cl-].[Na+]>S(=O)(=O)(O)O.C(O)C>[CH3:2][C:3]1[N:8]=[C:7]([OH:1])[CH:6]=[C:5]([Cl:10])[N:4]=1

Participants

7

Reactant 4

HCID 962WaterHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 2349974,6-Dichloro-2-methylpyrimidine

Product 1

HCID 178433455HCID 178433455, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1118Sulfuric AcidSolvent

Conditions

Temperature
23 °C

Procedure

To a solution of water (8.5 mL) in sulfuric acid (32 mL) was added 2-methyl-4,6-dichloropyrimidine (13.4 g, 82 mmol). The mixture was stirred for 1 hour at 23° C. and then poured onto an ice/water slurry containing sodium hydroxide (24 g, 600 mmol). When the ice had melted, sodium chloride (90 g) was added and allowed to dissolve. The product precipitated and was isolated by filtration (9.5 g) 80%. An analytical sample was prepared by recrystallization from ethanol m.p. 230°-234° C. as a fluffy yellow solid.

Workup

  1. dissolutionto dissolve
  2. customThe product precipitated
  3. customwas isolated by filtration (9.5 g) 80%

Sources & evidence

ORD record
ord-16ffd0da471f4c908594b6dfdab57384
Source dataset
uspto-grants-1986_10
Patent number
US04617393

Reaction notes

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