Water → HCID 178433455, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of water (8.5 mL) in sulfuric acid (32 mL) was added 2-methyl-4,6-dichloropyrimidine (13.4 g, 82 mmol). The mixture was stirred for 1 hour at 23° C. and then poured onto an ice/water slurry containing sodium hydroxide (24 g, 600 mmol). When the ice had melted, sodium chloride (90 g) was added and allowed to dissolve. The product precipitated and was isolated by filtration (9.5 g) 80%. An analytical sample was prepared by recrystallization from ethanol m.p. 230°-234° C. as a fluffy yellow solid.

Provenance & Evidence