Bromotrimethylsilane → HCID 53836494, compound

HRID 2290679Notes

Reaction equation

HRID 2290679 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][C:12]=2[Cl:21])=[CH:6][C:5]=1[N:22]([CH2:24][CH2:25][P:26]([O-:30])[O:27]CC)[CH3:23])([O-:3])=[O:2].C[Si](C)(C)Br>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:18])([F:19])[F:20])=[CH:13][C:12]=2[Cl:21])=[CH:6][C:5]=1[N:22]([CH2:24][CH2:25][P:26]([OH:30])[OH:27])[CH3:23])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 76113BromotrimethylsilaneHCID 70469830HCID 70469830, compound

Product 1

HCID 53836494HCID 53836494, compound

Conditions

Temperature
20 °C

Procedure

A mixture of 3.2 g of monoethyl N-[2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenyl]-N-methylaminoethylphosphonite and 10 g of trimethylbromosilane is stirred for 18 hours at 20° C. Excess trimethylbromosilane is removed by evaporation and the residue is then taken up in ethanol and the solution is evaporated, affording as residue a yellow oil which crystallises from ether. Yield: 2.14 g (71.3% of theory) of the title compound with a melting point of 161°-164° C.

Workup

  1. customExcess trimethylbromosilane is removed by evaporation
  2. customthe solution is evaporated
  3. customaffording as residue a yellow oil which
  4. customcrystallises from ether

Sources & evidence

ORD record
ord-18bfe671864949d899c2a63a51826e27
Source dataset
uspto-grants-1986_10
Patent number
US04618358

Reaction notes

Loading…