反应详情

3-Hydroxytetrahydrofuran (0.04 mole), toluene (50 ml) and triethylamine (0.04 mole) are charged into a glass reaction vessel equipped with a mechanical stirrer and adtition funnel. A solution of 2-nitro-5-(2-nitro-4-trifluoromethylphenoxy)benzoyl chloride (0.04 mole) in toluene (20 ml) is slowly added at room temperature with stirring. After the addition is completed, stirring is continued for a period of about eight hours. After this time, the reaction mixture is washed with water and dried over anhydrous magnesium sulfate. The dried solution is then stripped of solvent under reduced pressure leaving a residue. This residue is purified by silica gel chromatography using toluene and ethyl acetate/toluene mixture as the eluant to yield the desired product 3-tetrahydrofuryl 2-nitro-5-(2-nitro-4-trifluoromethylphenoxy)benzoate.

1. customequipped with a mechanical stirrer and adtition funnel
2. additionAfter the addition
3. stirringstirring
4. washAfter this time, the reaction mixture is washed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. customleaving a residue
7. customThis residue is purified by silica gel chromatography