Triethylamine → HCID 13731310, compound

HRID 2290687Notes

Reaction equation

HRID 2290687 reaction equation
[OH:1][CH:2]1[CH2:6][CH2:5][O:4][CH2:3]1.C(N(CC)CC)C.[CH3:14][S:15][C:16]1[CH:24]=[CH:23][C:22]([O:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=2)=[CH:21][C:17]=1[C:18](Cl)=[O:19]>C1(C)C=CC=CC=1>[CH3:14][S:15][C:16]1[CH:24]=[CH:23][C:22]([O:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:33])([F:34])[F:35])=[CH:28][CH:27]=2)=[CH:21][C:17]=1[C:18]([O:1][CH:2]1[CH2:6][CH2:5][O:4][CH2:3]1)=[O:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 99603-Furanol, tetrahydro-HCID 20229907HCID 20229907, compound

Product 1

HCID 13731310HCID 13731310, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

3-Hydroxytetrahydrofuran (0.04 mole), toluene (50 ml) and triethylamine (0.04 mole) are charged into a glass reaction vessel equipped with a mechanical stirrer and addition funnel. A solution of 2-methylthio-5-(4-trifluoromethylphenoxy)benzoyl chloride (0.04 mole) in toluene (20 ml) is slowly added at room temperature with stirring. After the addition is completed, stirring is continued for a period of about eight hours. After this time, the reaction mixture is washed with water and dried over anhydrous magnesium sulfate. The dried solution is then stripped of solvent under reduced pressure leaving a residue. This residue is purified by silica gel chromatography using toluene and ethyl acetate/toluene mixture as the eluant to yield the desired product 3-tetrahydrofuryl 2-methylthio-5-(4-trifluoromethylphenoxy)benzoate.

Workup

  1. customequipped with a mechanical stirrer and addition funnel
  2. additionAfter the addition
  3. stirringstirring
  4. washAfter this time, the reaction mixture is washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customleaving a residue
  7. customThis residue is purified by silica gel chromatography

Sources & evidence

ORD record
ord-d2c78426fd7f40c3915a642a8fccf0fb
Source dataset
uspto-grants-1986_10
Patent number
US04618359

Reaction notes

Loading…