4-Chloro-6-(2-pyridylmethoxy)pyrimidine → 6-(2-Pyridylmethoxy)pyrimidine

HRID 2290717Notes

Reaction equation

HRID 2290717 reaction equation
ClC1C=CC=CC=1C1C(C(OC)=O)=C(C)NC(COCCO)=C1C(OCC)=O.Cl[C:30]1[CH:35]=[C:34]([O:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][N:39]=2)[N:33]=[CH:32][N:31]=1>>[N:39]1[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=1[CH2:37][O:36][C:34]1[N:33]=[CH:32][N:31]=[CH:30][CH:35]=1

Participants

3

Reactant 2

HCID 202301564-Chloro-6-(2-pyridylmethoxy)pyrimidineHCID 703535674-(2-Chlorophenyl)-3-ethoxycarbonyl-2-(2-hydroxyethoxymethyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Product 1

HCID 202301606-(2-Pyridylmethoxy)pyrimidine

Procedure

4-<2-{[4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}ethoxy>-6-(2-pyridylmethoxy)pyrimidine was prepared by the method described in Example 13 using 4-(2-chlorophenyl)-3-ethoxycarbonyl-2-(2-hydroxyethoxymethyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine and 4-chloro-6-(2-pyridylmethoxy)pyrimidine as the starting materials. The product had m.p. 64°-67° C.

Sources & evidence

ORD record
ord-994cc87fa936424f96ddfed1530954ac
Source dataset
uspto-grants-1986_10
Patent number
US04618609

Reaction notes

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