4-Chloro-6-(1-methyl-2-imidazolylmethoxy)pyrimidine → 6-(1-Methyl-2-imidazolylmethoxy)pyrimidine

HRID 2290718Notes

Reaction equation

HRID 2290718 reaction equation
Cl[C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[N:11]([CH3:15])[CH:12]=[CH:13][N:14]=2)[N:5]=[CH:4][N:3]=1.ClC1C=CC=CC=1C1C(C(OC)=O)=C(C)NC(COCCO)=C1C(OCC)=O>>[CH3:15][N:11]1[CH:12]=[CH:13][N:14]=[C:10]1[CH2:9][O:8][C:6]1[N:5]=[CH:4][N:3]=[CH:2][CH:7]=1

Participants

3

Reactant 2

HCID 202301544-Chloro-6-(1-methyl-2-imidazolylmethoxy)pyrimidineHCID 703535674-(2-Chlorophenyl)-3-ethoxycarbonyl-2-(2-hydroxyethoxymethyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Product 1

HCID 867410766-(1-Methyl-2-imidazolylmethoxy)pyrimidine

Procedure

4-<2-{[4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}ethoxy>-6-(1-methyl-2-imidazolylmethoxy)pyrimidine was prepared by the method described in Example 13 using 4-chloro-6-(1-methyl-2-imidazolylmethoxy)pyrimidine and 4-(2-chlorophenyl)-3-ethoxycarbonyl-2-(2-hydroxyethoxymethyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine as the starting materials. The product had m.p. 48°-51° C.

Sources & evidence

ORD record
ord-7fc5356fcba34726b175f0018f64f52d
Source dataset
uspto-grants-1986_10
Patent number
US04618609

Reaction notes

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