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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2290718Generated: October 26, 2026

4-Chloro-6-(1-methyl-2-imidazolylmethoxy)pyrimidine → 6-(1-Methyl-2-imidazolylmethoxy)pyrimidine

https://huagongshe.com/reaction/2290718

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-6-(1-methyl-2-imidazolylmethoxy)pyrimidineHCID 20230154—
Reactant4-(2-Chlorophenyl)-3-ethoxycarbonyl-2-(2-hydroxyethoxymethyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridineHCID 70353567—
Product6-(1-Methyl-2-imidazolylmethoxy)pyrimidineHCID 86741076—

Reaction Steps

4-<2-{[4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl]methoxy}ethoxy>-6-(1-methyl-2-imidazolylmethoxy)pyrimidine was prepared by the method described in Example 13 using 4-chloro-6-(1-methyl-2-imidazolylmethoxy)pyrimidine and 4-(2-chlorophenyl)-3-ethoxycarbonyl-2-(2-hydroxyethoxymethyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine as the starting materials. The product had m.p. 48°-51° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04618609
Source datasetuspto-grants-1986_10
ORD IDord-7fc5356fcba34726b175f0018f64f52d
Source noteuspto-grants-1986_10