Methanol → HCID 136332163, compound

HRID 2290729Notes

Reaction equation

HRID 2290729 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=O)[C:12](=[N:14][OH:15])[CH3:13])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[NH2:17][NH:18][C:19]([NH2:21])=[S:20].CO.O>C(O)(=O)C>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[N:17][NH:18][C:19]([NH2:21])=[S:20])[C:12](=[N:14][OH:15])[CH3:13])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 887MethanolHCID 962WaterHCID 2723789ThiosemicarbazideHCID 73666220HCID 73666220, compound

Product 1

HCID 136332163HCID 136332163, compoundYield 68.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 4'-acetamido-2-hydroxyiminopropiophenone (1.87 g), thiosemicarbazide (1 g), methanol (15 ml), water (3 ml) and acetic acid (0.1 ml) was refluxed with stirring for 39 hours and then cooled. The resulting precipitate was collected by filtration, washed with methanol and dried to give 4'-acetamido-2-hydroxyiminopropiophenone thiosemicarbazone (1.7 g).

Workup

  1. temperaturewas refluxed
  2. temperaturecooled
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with methanol
  5. customdried

Sources & evidence

ORD record
ord-b82cd48088b144cba3d05a0a66f83b2e
Source dataset
uspto-grants-1986_10
Patent number
US04618610

Reaction notes

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