HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2290736Generated: October 31, 2026
Methyl isothiocyanate → 6-[4-(3-methylthioureido)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one
https://huagongshe.com/reaction/2290736
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one | HCID 13386033 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-[4-(3-methylthioureido)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one | HCID 54466127 | 99.4% |
Reaction Steps
A solution of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2 g) and methylisothiocyanate (0.788 g) in dimethylformamide (20 ml) was heated with stirring at 110° C. for 4 hours, followed by after-treatment in the same manner as Example 8 to give 6-[4-(3-methyl-thioureido)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (2.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04618610 |
|---|
| Source dataset | uspto-grants-1986_10 |
|---|
| ORD ID | ord-9bc32f950903457db0ab656fe372931a |
|---|
| Source note | uspto-grants-1986_10 |
|---|
