HCID 13386034, compound → HCID 13386056, compound
Reaction equation
C([NH:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:13]([CH3:19])[NH:14][C:15](=[O:18])[NH:16][N:17]=2)[CH:8]=[CH:9][C:10]=1[Cl:11])(=O)C>O.NN>[NH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:13]([CH3:19])[NH:14][C:15](=[O:18])[NH:16][N:17]=2)[CH:8]=[CH:9][C:10]=1[Cl:11]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A mixture of 6-(3-acetamido-4-chlorophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (34.75 g) and 100% hydrazine hydrate (100 ml) was heated at 100° C. for 3 hours. After cooling, the resulting crystals were recovered by filtration and washed with aqueous methanol to give 6-(3-amino-4-chlorophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (28.04 g).
Workup
- temperatureAfter cooling
- filtrationthe resulting crystals were recovered by filtration
- washwashed with aqueous methanol
Sources & evidence
- ORD record
- ord-72673fd450c741d5929e6bba595508eb
- Source dataset
- uspto-grants-1986_10
- Patent number
- US04618610
Reaction notes
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