HCID 20230478, compound → HCID 20230482, compound

HRID 2290765Notes

Reaction equation

HRID 2290765 reaction equation
[ClH:1].CS(NC1C=CC=CC=1)(=O)=O.Cl.[OH:14][C:15]1[CH:25]=[CH:24][C:23]([CH:26]([O:32][CH:33](C)[CH3:34])[CH2:27][NH:28][CH:29]([CH3:31])[CH3:30])=[CH:22][C:16]=1[NH:17][S:18]([CH3:21])(=[O:20])=[O:19]>C(O)C>[ClH:1].[OH:14][C:15]1[CH:25]=[CH:24][C:23]([CH:26]([O:32][CH2:33][CH3:34])[CH2:27][NH:28][CH:29]([CH3:30])[CH3:31])=[CH:22][C:16]=1[NH:17][S:18]([CH3:21])(=[O:20])=[O:19]

Participants

4

Reactant 2

HCID 20230478HCID 20230478, compoundHCID 23345680HCID 23345680, compound

Product 1

HCID 20230482HCID 20230482, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A 1-g sample of 2'-hydroxy-5'-[1-chloro-2-isopropylamino)ethyl]methanesulfonanilide hydrochloride is added to 10 mL of absolute ethanol and heated at reflux for 30 minutes. The mixture is evaporated to dryness, and the residue is washed with ethyl ether thus yielding the product compound. The same procedure is used to prepare 2'-hydroxy-5'-[1-isopropoxy-2-(isopropylamino)ethyl]methanesulfonanilide hydrochloride, m.p. 121-123, by substituting isopropanol for ethanol in the above reaction.

Workup

  1. temperatureheated
  2. temperatureat reflux for 30 minutes
  3. customThe mixture is evaporated to dryness
  4. washthe residue is washed with ethyl ether
  5. customthus yielding the product compound
  6. customin the above reaction

Sources & evidence

ORD record
ord-3f584d790ceb44c6b4ffc190472611f6
Source dataset
uspto-grants-1986_10
Patent number
US04618624

Reaction notes

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