HCID 20230478, compound → HCID 20230482, compound

Participants

Reaction Steps

A 1-g sample of 2'-hydroxy-5'-[1-chloro-2-isopropylamino)ethyl]methanesulfonanilide hydrochloride is added to 10 mL of absolute ethanol and heated at reflux for 30 minutes. The mixture is evaporated to dryness, and the residue is washed with ethyl ether thus yielding the product compound. The same procedure is used to prepare 2'-hydroxy-5'-[1-isopropoxy-2-(isopropylamino)ethyl]methanesulfonanilide hydrochloride, m.p. 121-123, by substituting isopropanol for ethanol in the above reaction.

Provenance & Evidence