Phenolate Sodium → HCID 20230481, compound

HRID 2290766Notes

Reaction equation

HRID 2290766 reaction equation
Cl.[OH:2][C:3]1[CH:13]=[CH:12][C:11]([CH:14](Cl)[CH2:15][NH:16][CH:17]([CH3:19])[CH3:18])=[CH:10][C:4]=1[NH:5][S:6]([CH3:9])(=[O:8])=[O:7].[O-:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[Na+]>O1CCCC1>[OH:2][C:3]1[CH:13]=[CH:12][C:11]([CH2:14][CH:15]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[NH:16][CH:17]([CH3:19])[CH3:18])=[CH:10][C:4]=1[NH:5][S:6]([CH3:9])(=[O:8])=[O:7]

Participants

4

Reactant 2

HCID 4445035Phenolate SodiumHCID 20230479HCID 20230479, compound

Product 1

HCID 20230481HCID 20230481, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A 3.25 g sample of 2'-hydroxy-5'-[1-chloro-2-(isopropylamino)ethyl]methanesulfonanilide hydrochloride is slowly added to 45 g of sodium phenoxide in 150 mL of dry tetrahydrofuran at 0° to 5° C. under N2 atmosphere. The mixture is stirred for 24 hours at ambient temperature and then poured on ice whereafter the crude product compound is separated.

Workup

  1. customis separated

Sources & evidence

ORD record
ord-69f66605c0354af89b86afe0f449759b
Source dataset
uspto-grants-1986_10
Patent number
US04618624

Reaction notes

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