Methyl iodide → HCID 86741081, compound

HRID 2290785Notes

Reaction equation

HRID 2290785 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH:5]([C:7]1[O:11][N:10]=[C:9]([CH2:12][CH2:13][S:14][CH3:15])[N:8]=1)[CH3:6].[CH3:25][I:26]>>[I-:26].[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH:5]([C:7]1[O:11][N:10]=[C:9]([CH2:12][CH2:13][S+:14]([CH3:25])[CH3:15])[N:8]=1)[CH3:6]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 20230254HCID 20230254, compound

Product 1

HCID 86741081HCID 86741081, compound

Procedure

A mixture of 0.2 g of 5-(3-fluoro-4-phenyl-α-methylbenzyl)-3-(2-methylthioethyl)-1,2,4-oxadiazole and 2 ml of methyl iodide was stirred and refluxed for 10 hours. After the mixture was concentrated to dryness under reduced pressure, the residue was triturated with diethyl ether, collected by filtration and dried to give [5-(3-fluoro-4-phenyl-α-methylbenzyl)1,2,4-oxadiazol-3-ylethyl]dimethylsulfonium iodide as light yellow fine crystals, m.p. 196.5° C. (decomp.).

Workup

  1. temperaturerefluxed for 10 hours
  2. concentrationAfter the mixture was concentrated to dryness under reduced pressure
  3. customthe residue was triturated with diethyl ether
  4. filtrationcollected by filtration
  5. customdried

Sources & evidence

ORD record
ord-47b9efac3e3345089d84333c185b7444
Source dataset
uspto-grants-1986_10
Patent number
US04618617

Reaction notes

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