Ebselen → HCID 18604983, compound

HRID 2290788Notes

Reaction equation

HRID 2290788 reaction equation
[C:1]1([N:7]2[C:11](=[O:12])[C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[Se:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:17][C@H:18]([C:21]([OH:23])=[O:22])[CH2:19][SH:20]>CO>[C:1]1([NH:7][C:11]([C:10]2[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=2[Se:8][S:20][CH2:19][C@@H:18]([C:21]([OH:23])=[O:22])[NH2:17])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 3194EbselenHCID 5862L-(+)-Cysteine

Product 1

HCID 18604983HCID 18604983, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2,74 g (10 mmol) 2-phenyl-1,2-benzoisoselenazole-3(2H)-one and 1,21 g (10 mmol) L-cysteine are dissolved in 25 ml trifluororacetic acid. This solution is stirred for 18 hours at room temperature. Then, 150 ml of an ice-water mixture are added to this solution. The deposited precipitate after some stirring becomes solid. It is sucked off and finally dissolved in methanol. After evaporation of the solvent, a residue remains which is washed with ether.

Workup

  1. customAfter evaporation of the solvent
  2. washis washed with ether

Sources & evidence

ORD record
ord-bd2047e3ef9841acadfecba3b7b430e4
Source dataset
uspto-grants-1986_10
Patent number
US04618669

Reaction notes

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