Water → HCID 13579603, compound

HRID 2290795Notes

Reaction equation

HRID 2290795 reaction equation
[CH3:1][CH2:2][CH2:3][CH:4]([OH:11])[CH2:5][CH2:6][CH:7](O)[CH:8]=C.I(O)(=O)(=O)=[O:13].[OH2:17]>>[OH:17][CH:1]1[CH2:2][CH:3]2[CH:7]([CH:6]=[CH:5][C:4]2=[O:11])[CH2:8][O:13]1

Participants

4

Reactant 3

HCID 962WaterHCID 65185Metaperiodic acidHCID 57164991HCID 57164991, compound

Product 1

HCID 13579603HCID 13579603, compoundYield 59.5%

Procedure

At first, 205 mg of compound (III) is dissolved in 3 ml of water, and 202 mg of periodic acid is added thereto. The mixture is stirred at room temperature for 1 hour and 30 minutes, and then chromatographically purified (HP-20SS 20 ml, water : methanol=4:1) to obtain 101 mg of compound (I) (59.5%).

Workup

  1. customchromatographically purified (HP-20SS 20 ml, water : methanol=4:1)

Sources & evidence

ORD record
ord-b9fcbf58be334bcc8fe75778eecbd793
Source dataset
uspto-grants-1986_10
Patent number
US04618687

Reaction notes

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