Hydroxyurea → HCID 13770900, compound

HRID 2290840Notes

Reaction equation

HRID 2290840 reaction equation
[CH2:1]1[CH:7](O)[NH:6][P:4]([N:9]([CH2:13][CH2:14][Cl:15])[CH2:10][CH2:11][Cl:12])(=[O:5])[O:3][CH2:2]1.[OH:16][NH:17][C:18]([NH2:20])=[O:19].ClC(Cl)(Cl)C(O)=O>O>[OH:16][N:17]([CH:7]1[CH2:1][CH2:2][O:3][P:4]([N:9]([CH2:13][CH2:14][Cl:15])[CH2:10][CH2:11][Cl:12])(=[O:5])[NH:6]1)[C:18]([NH2:20])=[O:19]

Participants

5

Reactant 3

HCID 3657HydroxyureaHCID 6421Trichloroacetic AcidHCID 997354-Hydroxycyclophosphamide

Product 1

HCID 13770900HCID 13770900, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

16 g (58 mmol) of 4-hydroxycyclophosphamide and 5.2 g (68 mmol) of hydroxyurea were dissolved in 160 ml of water, acidified with trichloracetic acid (pH 3-4) and left to stand for 20 hours at 0° C. in a refrigerator. The crystal sludge was then drawn off by suction, washed with water, dried over P2O5 under high vacuum and recrystallized from methanol/chloroform.

Workup

  1. waitleft
  2. washwashed with water
  3. dry with materialdried over P2O5 under high vacuum
  4. customrecrystallized from methanol/chloroform

Sources & evidence

ORD record
ord-07868e20d6d14280abe33c2de333dd9c
Source dataset
uspto-grants-1986_10
Patent number
US04618692

Reaction notes

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