HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trichloroacetic Acid → N-{2-[Bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda~5~-oxazaphosphinan-4-yl}-N-hydroxymorpholine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trichloroacetic Acid | HCID 6421 | — |
| Reactant | 4-Hydroxycyclophosphamide | HCID 99735 | — |
| Reactant | HCID 20230814 | HCID 20230814 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-{2-[Bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda~5~-oxazaphosphinan-4-yl}-N-hydroxymorpholine-4-carboxamide | HCID 13770903 | — |
Reaction Steps
1.2 g (4.3 mmol) of 4-hydroxycyclophosphamide in 15 ml of acetone were treated with 630 mg (4.3 mmol) of N-hydroxymorpholino-carboxamide and a trace of trichloroacetic acid and stored at -25° C. After 4 days the crystals were drawn off by suction and recrystallized from acetone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04618692 |
| Source dataset | uspto-grants-1986_10 |
| ORD ID | ord-b4b21d04e6124ccb902df70fb26abe8e |
| Source note | uspto-grants-1986_10 |