反应详情

A mixture of 15.0 g of 1-(4-chlorobenzyl)piperazine, 14.4 g of 1-bromo-2-chloroethane and 150 ml of tetrahydrofuran was refluxed for 8 hours. The solvent was removed in vacuo, and 2N sodium hydroxide was added to the residue. The product was extracted with methylene chloride, and the extract was dried (sodium sulfate) and concentrated. The salt was precipitated with ethereal hydrochloric acid to give 13.8 g (56% of theory) of 1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride as a white crystalline solid.

1. temperaturewas refluxed for 8 hours
2. customThe solvent was removed in vacuo, and 2N sodium hydroxide
3. additionwas added to the residue
4. extractionThe product was extracted with methylene chloride
5. dry with materialthe extract was dried (sodium sulfate)
6. concentrationconcentrated
7. customThe salt was precipitated with ethereal hydrochloric acid