1-Bromo-3-chloropropane → HCID 13731112, compound

HRID 2290893Notes

Reaction equation

HRID 2290893 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:4][CH:3]=1.Br[CH2:19][CH2:20][CH2:21][Cl:22].[OH-].[K+]>CS(C)=O>[ClH:1].[ClH:22].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH2:21][Cl:22])[CH2:16][CH2:17]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 80061-Bromo-3-chloropropaneHCID 14797Potassium HydroxideHCID 14097058Piperazine,1-[4-(4-chlorophenyl)butyl]-

Product 1

HCID 13731112HCID 13731112, compoundYield 125.7%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The procedure described in Example 1(a) was followed, using 10.0 g of 4-(4-chlorophenyl)butyl piperazine, 47.2 g of 1-bromo-3-chloropropane, 150 ml of dimethyl sulfoxide and 11.2 g of potassium hydroxide, to give 10.0 g (82% of theory) of 1-[4-(4-chlorophenyl)butyl]-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid, M.p. 266°-268° C.

Sources & evidence

ORD record
ord-e04fb43ac56b4831b505ab256c1e5477
Source dataset
uspto-grants-1986_10
Patent number
US04618677

Reaction notes

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