Triethylamine → HCID 178418504, compound

HRID 2290902Notes

Reaction equation

HRID 2290902 reaction equation
[C:1]([N:5]=[C:6]=[O:7])([CH3:4])([CH3:3])[CH3:2].[ClH:8].Cl.[Cl:10][C:11]1[CH:27]=[CH:26][C:14]([CH2:15][N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][SH:25])[CH2:18][CH2:17]2)=[CH:13][CH:12]=1.C(N(CC)CC)C>C(Cl)Cl>[OH2:7].[ClH:10].[ClH:8].[C:1]([NH:5][C:6](=[SH:25][CH2:24][CH2:23][CH2:22][N:19]1[CH2:20][CH2:21][N:16]([CH2:15][C:14]2[CH:13]=[CH:12][C:11]([Cl:10])=[CH:27][CH:26]=2)[CH2:17][CH2:18]1)[OH:7])([CH3:4])([CH3:3])[CH3:2].[OH2:7].[OH2:7].[C:1]([NH:5][C:6](=[SH:25][CH2:24][CH2:23][CH2:22][N:19]1[CH2:20][CH2:21][N:16]([CH2:15][C:14]2[CH:13]=[CH:12][C:11]([Cl:10])=[CH:27][CH:26]=2)[CH2:17][CH2:18]1)[OH:7])([CH3:4])([CH3:3])[CH3:2].[ClH:10].[ClH:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62412tert-Butyl isocyanateHCID 137311183-[4-(4-Chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride

Product 1

HCID 178418504HCID 178418504, compoundYield 140.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The procedure described in Example 2 was followed, using 0.8 g of t-butyl isocyanate, 3.0 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride, 1.6 g of triethylamine and 75 ml of methylene chloride, to give 2.2 g (60% of theory) of N-(t-butyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride sesquihydrate as a white crystalline solid, M.p. 246°-248° C.

Sources & evidence

ORD record
ord-dc672b869372425da7025e1c330f35f5
Source dataset
uspto-grants-1986_10
Patent number
US04618677

Reaction notes

Loading…