HCID 13746018, compound → HCID 13746019, compound

HRID 2290909Notes

Reaction equation

HRID 2290909 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([N:14]2[CH2:22][CH:21]3[CH:16]([CH2:17][CH2:18][C:19]4[C:26]([O:27][CH3:28])=[C:25]([O:29][CH3:30])[CH:24]=[CH:23][C:20]=43)[CH2:15]2)=[O:13])=[CH:6][CH:5]=1)([O-])=O>[Ni].COCCO>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]([N:14]2[CH2:22][CH:21]3[CH:16]([CH2:17][CH2:18][C:19]4[C:26]([O:27][CH3:28])=[C:25]([O:29][CH3:30])[CH:24]=[CH:23][C:20]=43)[CH2:15]2)=[O:13])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 13746018HCID 13746018, compound

Product 1

HCID 13746019HCID 13746019, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 80192-MethoxyethanolSolvent

Procedure

A mixture of the compound of example 14 (1.83 g, 4.5 mmole), 2 g of Raney Nickel, and 250 mL of 2-methoxyethanol was hydrogenated at 3 atmospheres in a Parr shaker for 0.5 hour. The resulting mixture was filtered and evaporated to give 1.8 g (71%) as a brown oil; M+ 380.

Workup

  1. filtrationThe resulting mixture was filtered
  2. customevaporated
  3. customto give 1.8 g (71%) as a brown oil

Sources & evidence

ORD record
ord-4997fab97a244b87ac47524a079646c4
Source dataset
uspto-grants-1986_10
Patent number
US04618683

Reaction notes

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