Hydrochloric Acid → HCID 20230722, compound

HRID 2290912Notes

Reaction equation

HRID 2290912 reaction equation
B.C1COCC1.[CH3:7][O:8][C:9]1[CH:23]=[CH:22][C:12]2[CH:13]3[CH:17]([CH2:18][CH2:19][C:11]=2[CH:10]=1)[C:16](=O)[NH:15][C:14]3=O.[ClH:24]>>[ClH:24].[CH3:7][O:8][C:9]1[CH:23]=[CH:22][C:12]2[CH:13]3[CH:17]([CH2:18][CH2:19][C:11]=2[CH:10]=1)[CH2:16][NH:15][CH2:14]3

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 2723981Borane;tetrahydrofuranHCID 20230705HCID 20230705, compound

Product 1

HCID 20230722HCID 20230722, compound

Procedure

BH3.THF (1M solution, 52 mL) was added to the compound of example 20 (1.5 g, 6.5 mmole). The reaction mixture was stirred at reflux for 2 hrs., cooled to 0°, and 10 mL 6N HCl added. After 2 hours reflux, solvents were evaporated. CH3CN was added and evaporated several times. The residue was crystallized from MeOH/Et2O to obtain 1.0 g white solid; M+ 203.

Workup

  1. temperatureat reflux for 2 hrs
  2. temperature, cooled to 0°
  3. temperatureAfter 2 hours reflux
  4. customsolvents were evaporated
  5. additionCH3CN was added
  6. customevaporated several times
  7. customThe residue was crystallized from MeOH/Et2O

Sources & evidence

ORD record
ord-d4f17fff4190430d944b6dd5c2c1fa24
Source dataset
uspto-grants-1986_10
Patent number
US04618683

Reaction notes

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