反应详情

A solution of ethyl-4-keto-γ-(2-methoxy-5-methylphenyl)-butyrate (180 g, 0.81 mole) and 1200 mL 20% NaOH was stirred at reflux for 3 hours. After cooling to 0°, the solution was acidified with concentrated HCl. The solid was filtered, washed with water, dried (in-vacuo) to yield 145 g orange solid. Recrystallization from CCl4 yielded 123 g light yellow powder, (68%).

1. temperatureat reflux for 3 hours
2. temperatureAfter cooling to 0°
3. filtrationThe solid was filtered
4. washwashed with water
5. customdried (in-vacuo)