Potassium Acetate → 2-(6-Methoxy-2-naphthyl)propionic acid

HRID 2290943Notes

Reaction equation

HRID 2290943 reaction equation
Br[CH:2]([C:4]1([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:19][CH3:20])[CH:15]=3)[CH:10]=2)OCCO1)C.[C:21]([O-:24])(=[O:23])C.[K+]>C(N)=O>[CH3:20][O:19][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9]([CH:4]([CH3:2])[C:21]([OH:24])=[O:23])[CH:18]=[CH:17]2

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 15908760HCID 15908760, compound

Product 1

HCID 13022-(6-Methoxy-2-naphthyl)propionic acidYield 52%

Reagents, catalysts & solvents 1

HCID 713FormamideSolvent

Conditions

Temperature
170 °C

Procedure

A mixture of 2-(1-bromoethyl)-2-(6-methoxy-2-naphthyl)-1,3-dioxolane (3.37 g; 10 mmol), potassium acetate (1.2 g; 12 mmol) and formamide (50 ml) is heated under stirring at 170° C. for 2.5 h. The reaction mixture is worked up as described in example 1a to provide 2-(6-methoxy-2-naphthyl)-propionic acid (yield 52%).

Workup

  1. temperatureis heated

Sources & evidence

ORD record
ord-4e18544986444607876e1f4943c4e066
Source dataset
uspto-grants-1986_10
Patent number
US04618697

Reaction notes

Loading…