Potassium Acetate → 2-(6-Methoxy-2-naphthyl)propionic acid

HRID 2290944Notes

Reaction equation

HRID 2290944 reaction equation
Br[CH:2]([C:4]1([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([O:20][CH3:21])[CH:16]=3)[CH:11]=2)OCCCO1)C.[C:22]([O-:25])(=[O:24])C.[K+]>C(N)=O>[CH3:21][O:20][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([CH:4]([CH3:2])[C:22]([OH:25])=[O:24])[CH:19]=[CH:18]2

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 13432071HCID 13432071, compound

Product 1

HCID 13022-(6-Methoxy-2-naphthyl)propionic acidYield 53%

Reagents, catalysts & solvents 1

HCID 713FormamideSolvent

Conditions

Temperature
170 °C

Procedure

A mixture of 2-(1-bromoethyl)-2-(6-methoxy-2-naphthyl)-1,3-dioxane (3.79 g; 10 mmol), potassium acetate (1.2 g; 12 mmol) and formamide (50 ml) is heated at 170° C. under stirring for 2.5 h. The reaction mixture is worked up as described in example 1a to provide 2-(6-methoxy-2-naphthyl)-propionic acid (yield 53%).

Sources & evidence

ORD record
ord-26473ae0abb5483c87aaa42f9102bd24
Source dataset
uspto-grants-1986_10
Patent number
US04618697

Reaction notes

Loading…