Hydrochloric Acid → FSCZNKNUJVBMPY-UHFFFAOYSA-N

HRID 2290981Notes

Reaction equation

HRID 2290981 reaction equation
C([O:8][C:9](=[O:23])[CH2:10][NH:11][C:12](=[O:22])[C:13]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH2:14])C1C=CC=CC=1.CO.[OH-].[Na+].Cl>O>[CH2:15]([C:13](=[CH2:14])[C:12]([NH:11][CH2:10][C:9]([OH:23])=[O:8])=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 13242778Benzyl N-(2-benzylacryloyl)glycinate

Product 1

HCID 13242777FSCZNKNUJVBMPY-UHFFFAOYSA-N

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.10 (6.8 mmoles) of N-(2-benzyl propenoyl-glycine benzyl ester, M.P. =60° C, are stirred at 10° C. for 2 hours with a mixture of 30 ml of methanol and 0.27 g of NaOH (6.8 mmoles), dissolved in 5 ml of water. The pH is brought to 1 by the addition of 2N HCl and the material is extracted with ethyl acetate. The solvent is washed with 2×20 ml of water, dried and evaporated under a vacuum. 1.36 g of crystals are obtained.

Workup

  1. extractionthe material is extracted with ethyl acetate
  2. washThe solvent is washed with 2×20 ml of water
  3. customdried
  4. customevaporated under a vacuum

Sources & evidence

ORD record
ord-f826b4d5a1604ef785a6739d815597e7
Source dataset
uspto-grants-1986_10
Patent number
US04618708

Reaction notes

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