Methyl Isocyanate → HCID 13690936, compound

HRID 2290988Notes

Reaction equation

HRID 2290988 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([Cl:12])=[C:6]([C:8]([CH3:11])([CH3:10])[CH3:9])[CH:7]=1.[CH3:13][N:14]=[C:15]=[O:16]>C(Cl)Cl.C(N(CC)CC)C>[Cl:12][C:5]1[N:4]=[N:3][C:2]([NH:1][C:15]([NH:14][CH3:13])=[O:16])=[CH:7][C:6]=1[C:8]([CH3:9])([CH3:11])[CH3:10]

Participants

5

Reactant 2

HCID 12228Methyl Isocyanate2×HCID 1637143-Pyridazinamine, 6-chloro-5-(1,1-dimethylethyl)-

Product 1

HCID 13690936HCID 13690936, compound

Reagents, catalysts & solvents 2

HCID 8471TriethylamineCatalystHCID 6344DichloromethaneSolvent2×

Procedure

To a mixture of 1.3 g of (0.007 mole) of 3-amino-6-chloro-5-(1,1-dimethylethyl)pyridazine in 65 ml of methylene chloride was added one drop of triethylamine and 0.8 g (0.014 mole, 2.0 equivalents) of methyl isocyanate. The mixture was stirred at room temperature for about 18 hours. Additional methyl isocyanate (0.8 g, 0.140 mole, 2.0 equivalents) was added and about 3 hours later, the solution was diluted to 400 ml using methylene chloride. The solution was washed with four 40-ml portions of 1.0N hydrochloric acid and 50 ml of water, and was then dried with magnesium sulfate.

Workup

  1. additionthe solution was diluted to 400 ml
  2. washThe solution was washed with four 40-ml portions of 1.0N hydrochloric acid and 50 ml of water
  3. dry with materialwas then dried with magnesium sulfate

Sources & evidence

ORD record
ord-a1a9d47bb9404b8085f177c37bb72548
Source dataset
uspto-grants-1986_10
Patent number
US04619686

Reaction notes

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