Sodium Hydroxide → HCID 178516723, compound

HRID 2291104Notes

Reaction equation

HRID 2291104 reaction equation
O.NN.[F:4][C:5]([F:19])([F:18])[C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([OH:16])[CH:10]=[N+:9]2[O-].[OH-].[Na+]>>[F:19][C:5]([F:4])([F:18])[C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[C:11]([OH:16])[CH:10]=[N:9]2

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 178526282HCID 178526282, compound

Product 1

HCID 178516723HCID 178516723, compoundYield 94%

Procedure

The treated catalyst (I) (containing 0.3 g of metallic nickel) and 4.0 g of a 80% aqueous hydrazine hydrate solution were added dropwise to 300 g of an aqueous solution containing 23.0 g of 6-trifluoromethyl-2-quinoxalinol-4-oxide and 8 g of sodium hydroxide at 40° to 50° C., and the reaction was carried out at 40° to 80° C. for 5 hr. After the catalyst was removed by filtration, the filtrate was acidified to give 20.1 g (yield 94%) of 6-trifluoromethyl-2-quinoxalinol with melting point of 260° C.

Workup

  1. customAfter the catalyst was removed by filtration

Sources & evidence

ORD record
ord-cd841b1ab1854916aeb4e8adb4b8264a
Source dataset
uspto-grants-1986_10
Patent number
US04620003

Reaction notes

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