Hydrochloric Acid → HCID 13064834, compound

HRID 2291188Notes

Reaction equation

HRID 2291188 reaction equation
[O:1]=[C:2]([C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[NH:29][C:28](=[O:33])[CH2:27][CH2:26]2)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9](C2C=CC(OCC)=CC2=C=O)[CH2:8][CH2:7]1.[OH-:34].[Na+].[ClH:36]>CO>[ClH:36].[O:1]=[C:2]([C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[NH:29][C:28](=[O:33])[CH2:27][CH2:26]2)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([C:30]2[CH:25]=[CH:24][C:23]([C:2]([OH:1])=[O:34])=[CH:32][CH:31]=2)[CH2:10][CH2:11]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 131714512HCID 131714512, compound

Product 1

HCID 13064834HCID 13064834, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.0 Grams of 6-{1-oxo-4-[4-(4-ethoxy-carbonylphenyl)-1-piperazinyl]butyl}-3,4-dihydrocarbostyril and 0.6 g of sodium hydroxide were mixed in 70 ml of methanol and refluxed by heating for 2 hours. To the reaction mixture was added 5 ml of concentrated hydrochloric acid and the mixture was concentrated under a reduced pressure to dryness. The residue was recrystallized from ethanol-water to obtain 0.6 g of 6-{1-oxo-4-[4-(4-carboxyphenyl)-1-piperazinyl]butyl}-3,4-dihydrocarbostyril monohydrochloride in colorless needle-like crystals.

Workup

  1. temperaturerefluxed
  2. temperatureby heating for 2 hours
  3. concentrationthe mixture was concentrated under a reduced pressure to dryness
  4. customThe residue was recrystallized from ethanol-water

Sources & evidence

ORD record
ord-f6e319538a76497ca6008b55457f8bd4
Source dataset
uspto-grants-1986_10
Patent number
US04619932

Reaction notes

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