Dimethyl Sulfate → HCID 21279520, compound

HRID 2291217Notes

Reaction equation

HRID 2291217 reaction equation
[CH3:1]C(C)([O-])C.[K+].[CH2:7]([S:14][C:15]1[N:16]=[C:17]2[S:22][CH:21]([CH3:23])[C:20](=[O:24])[N:18]2[N:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.S(OC)(OC)(=O)=O>CN(C)C=O>[CH2:7]([S:14][C:15]1[N:16]=[C:17]2[S:22][C:21]([CH3:23])=[C:20]([O:24][CH3:1])[N:18]2[N:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 21279508HCID 21279508, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 21279520HCID 21279520, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Potassium t-butoxide (2.6 g) was added to a solution of the product of stage (b) in dimethylformamide (30 ml) with stirring and cooling. After 10 minutes, this solution was treated with dimethyl sulphate (2.8 g) and stirring was continued for 4 hours. Addition to ice/water/ether and filtration gave 2.3 g of desired product, mp 101°-103° C.

Workup

  1. temperaturecooling
  2. stirringstirring
  3. waitwas continued for 4 hours
  4. additionAddition
  5. filtrationto ice/water/ether and filtration

Sources & evidence

ORD record
ord-533e2f2f3db145cb8810a17105a99f3a
Source dataset
uspto-grants-1989_01
Patent number
US04795483

Reaction notes

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