2-Furancarboxylic acid → 6-Methoxy-1-naphthoic acid

HRID 2291247Notes

Reaction equation

HRID 2291247 reaction equation
[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O1[CH:13]=[CH:12][CH:11]=[C:10]1[C:14]([OH:16])=[O:15].[Cl-].[Cl-].[Cl-].[Al+3]>>[CH3:8][O:7][C:1]1[CH:6]=[C:5]2[C:4](=[CH:3][CH:2]=1)[C:10]([C:14]([OH:16])=[O:15])=[CH:11][CH:12]=[CH:13]2

Participants

4

Reactant 3

HCID 69192-Furancarboxylic acidHCID 7519AnisoleHCID 6451240Aluminum(III) Chloride

Product 1

HCID 44137086-Methoxy-1-naphthoic acid

Procedure

This starts from anisole; this is reacted with furan-2-carboxylic acid in the presence of a large excess of aluminium trichloride to give 6-methoxy-naphthalene-1-carboxylic acid (see J. Am. Chem. Soc. 69, page 2262 and European Patent No. A1-200,840).

Sources & evidence

ORD record
ord-e2bdbe5a3ed0451ab5e46c42be3181d5
Source dataset
uspto-grants-1989_01
Patent number
US04795596

Reaction notes

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