Hydrochloric Acid → Diltiazem

HRID 2291252Notes

Reaction equation

Cl.Cl.[C:3]([O:6][CH:7]1[C:13](=[O:14])[N:12]([CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])[C:11]2[CH:20]=[CH:21][CH:22]=[CH:23][C:10]=2[S:9][CH:8]1[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=1)(=[O:5])[CH3:4]>>[CH3:4][C:3]([O:6][C@H:7]1[C:13](=[O:14])[N:12]([CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])[C:11]2[CH:20]=[CH:21][CH:22]=[CH:23][C:10]=2[S:9][C@H:8]1[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=1)=[O:5]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 2144641,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1)

Product 1

HCID 39186Diltiazem

Procedure

HCl: 3-acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride

Sources & evidence

ORD record: ord-08a9a6154bcd484089b5fe97fcff2854
Source dataset: uspto-grants-1989_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04795643

Reaction notes

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