N-Methylhomoveratrylamine → HCID 21279707, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5 g of 2-chloro-4-amino-6,7-dimethoxy quinazoline, 30 g of N-methyl-homoveratryl amine (Lloydia 33, 15-18) and 1 g of triethylbenzyl ammonium chloride was heated with stirring to 110° C. over a 3 hour period. Then the excess of N-methyl-homoveratryl amine was distilled off in vacuo. On standing in the cold, a precipitate was formed from the solution of the evaporation residue in acetone. After filtration with activated charcoal, the precipitate was recrystallized from methanol. The N-methyl-N-(4-amino-6,7-dimethoxy-quinazolin-2-yl)-homoveratryl amine hydrochloride obtained melted at 265°-270° C. with decomposition.

Provenance & Evidence