HuagongsheHuagongshe Chemistry Print Report · For research reference only
Gamma-Butyrolactone → HCID 13938924, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Gamma-Butyrolactone | HCID 7302 | — |
| Reactant | 2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline | HCID 616267 | — |
| Product | HCID 13938924 | HCID 13938924 | — |
Reaction Steps
5 g of 2-piperazinyl-4-amino-6,7-dimethoxy quinazoline were heated in 15 g of γ-butyrolactone to 100° C. until a sample on thin layer chromatography (as described in Examples 1 and 3) indicated the reaction was complete. The precipitate formed overnight with cooling was removed and recrystallized from ethanol. The 1-(4-amino-6,7-dimethoxy quinazolin-2-yl)-4-(4-hydroxy-butyryl)-piperazine obtained showed a crystal transformation at 135°-140° C. and melted at 241°-243° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04795750 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-a34267fc36174ac290f95ab2a2dd836a |
| Source note | uspto-grants-1989_01 |